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6zzj

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Current revision (12:00, 1 February 2024) (edit) (undo)
 
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<StructureSection load='6zzj' size='340' side='right'caption='[[6zzj]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='6zzj' size='340' side='right'caption='[[6zzj]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6zzj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corgl Corgl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6zzj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum_ATCC_13032 Corynebacterium glutamicum ATCC 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAO:OXIDIZED+COENZYME+A'>CAO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aceF, sucB, Cgl2207, cg2421 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196627 CORGL])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAO:OXIDIZED+COENZYME+A'>CAO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zzj OCA], [https://pdbe.org/6zzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zzj RCSB], [https://www.ebi.ac.uk/pdbsum/6zzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zzj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zzj OCA], [https://pdbe.org/6zzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zzj RCSB], [https://www.ebi.ac.uk/pdbsum/6zzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zzj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ODP2_CORGL ODP2_CORGL]] Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF.<ref>PMID:20675489</ref>
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[https://www.uniprot.org/uniprot/ODP2_CORGL ODP2_CORGL] Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF.<ref>PMID:20675489</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6zzj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6zzj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrolipoamide acetyltransferase 3D structures|Dihydrolipoamide acetyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Corgl]]
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[[Category: Corynebacterium glutamicum ATCC 13032]]
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[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bellinzoni, M]]
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[[Category: Bellinzoni M]]
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[[Category: Bruch, E M]]
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[[Category: Bruch EM]]
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[[Category: Lexa-Sapart, N]]
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[[Category: Lexa-Sapart N]]
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[[Category: Acetyltransferase]]
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[[Category: Coa]]
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[[Category: Corynebacterium]]
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[[Category: Lipoamide]]
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[[Category: Odh]]
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[[Category: Pdh]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the catalytic domain of Corynebacterium glutamicum acetyltransferase AceF (E2p) in complex with oxidized CoA.

PDB ID 6zzj

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