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7dkn

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Current revision (16:35, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7dkn' size='340' side='right'caption='[[7dkn]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
<StructureSection load='7dkn' size='340' side='right'caption='[[7dkn]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7dkn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DKN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7dkn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DKN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dkn OCA], [https://pdbe.org/7dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dkn RCSB], [https://www.ebi.ac.uk/pdbsum/7dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dkn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dkn OCA], [https://pdbe.org/7dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dkn RCSB], [https://www.ebi.ac.uk/pdbsum/7dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dkn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
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[https://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Iizuka, Y]]
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[[Category: Sulfurisphaera tokodaii str. 7]]
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[[Category: Kikuchi, M]]
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[[Category: Iizuka Y]]
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[[Category: Tsunoda, M]]
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[[Category: Kikuchi M]]
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[[Category: Yamauchi, T]]
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[[Category: Tsunoda M]]
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[[Category: Methyltransferase]]
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[[Category: Yamauchi T]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase

PDB ID 7dkn

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