1fxx

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[[Image:1fxx.jpg|left|200px]]
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{{Seed}}
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[[Image:1fxx.png|left|200px]]
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{{STRUCTURE_1fxx| PDB=1fxx | SCENE= }}
{{STRUCTURE_1fxx| PDB=1fxx | SCENE= }}
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'''THE STRUCTURE OF EXONUCLEASE I SUGGESTS HOW PROCESSIVITY IS ACHIEVED'''
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===THE STRUCTURE OF EXONUCLEASE I SUGGESTS HOW PROCESSIVITY IS ACHIEVED===
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==Overview==
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Exonuclease I (ExoI) from Escherichia coli is a monomeric enzyme that processively degrades single stranded DNA in the 3' to 5' direction and has been implicated in DNA recombination and repair. Determination of the structure of ExoI to 2.4 A resolution using X-ray crystallography verifies the expected correspondence between a region of ExoI and the exonuclease (or proofreading) domains of the DNA polymerases. The overall fold of ExoI also includes two other regions, one of which extends the exonuclease domain and another that can be described as an elaborated SH3 domain. These three regions combine to form a molecule that is shaped like the letter C, although it also contains a segment that effectively converts the C into an O-like shape. The structure of ExoI thus provides additional support for the idea that DNA metabolizing enzymes achieve processivity by completely enclosing the DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_11101894}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11101894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11101894}}
==About this Structure==
==About this Structure==
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[[Category: Dnaq superfamily]]
[[Category: Dnaq superfamily]]
[[Category: Sh3-like domain]]
[[Category: Sh3-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:53:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:06:17 2008''

Revision as of 01:06, 1 July 2008

Image:1fxx.png

Template:STRUCTURE 1fxx

THE STRUCTURE OF EXONUCLEASE I SUGGESTS HOW PROCESSIVITY IS ACHIEVED

Template:ABSTRACT PUBMED 11101894

About this Structure

1FXX is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of Escherichia coli exonuclease I suggests how processivity is achieved., Breyer WA, Matthews BW, Nat Struct Biol. 2000 Dec;7(12):1125-8. PMID:11101894

Page seeded by OCA on Tue Jul 1 04:06:17 2008

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