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| - | [[Image:1fxz.gif|left|200px]] | + | {{Seed}} |
| | + | [[Image:1fxz.png|left|200px]] |
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| | {{STRUCTURE_1fxz| PDB=1fxz | SCENE= }} | | {{STRUCTURE_1fxz| PDB=1fxz | SCENE= }} |
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| - | '''CRYSTAL STRUCTURE OF SOYBEAN PROGLYCININ A1AB1B HOMOTRIMER'''
| + | ===CRYSTAL STRUCTURE OF SOYBEAN PROGLYCININ A1AB1B HOMOTRIMER=== |
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| - | ==Overview==
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| - | Soybean glycinin is a member of the 11 S globulin family. The crystal structure of proglycinin was determined by X-ray crystallography at 2.8 A resolution with an R-factor of 0.199 and a free R-factor of 0.250. A trimer molecule was found in an asymmetric unit of crystals. The trimer model contains three A1aB1b subunits and comprises 1128 amino acid residues and 34 water molecules. The constituent protomers of the homo-trimeric protein are arranged around a 3-fold symmetry axis with dimensions of 95 Ax95 Ax40 A. The protomer model is composed of five fragments which correspond roughly to conserved regions based on the sequence alignment of various 11 S globulins. The core of the protomer consists of two jelly-roll beta-barrels and two extended helix domains. This structure of proglycinin is similar to those of canavalin and phaseolin belonging to the 7 S globulin family, strongly supporting the hypothesis that both 7 S and 11 S globulins are derived from a common ancestor. The inter and intra-chain disulfide bonds conserved in the 11 S globulin family are clearly observed. It is found that the face with the inter-chain disulfide bond (IE face) contains more hydrophobic residues than that with the intra-chain disulfide bond. This suggests that a mature hexamer is formed by the interaction between the IE faces after processing.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_11124907}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 11124907 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_11124907}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Proglycinin]] | | [[Category: Proglycinin]] |
| | [[Category: Seed storage protein]] | | [[Category: Seed storage protein]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:53:25 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:06:40 2008'' |
Revision as of 01:06, 1 July 2008
Template:STRUCTURE 1fxz
CRYSTAL STRUCTURE OF SOYBEAN PROGLYCININ A1AB1B HOMOTRIMER
Template:ABSTRACT PUBMED 11124907
About this Structure
1FXZ is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.
Reference
Crystal structure of soybean proglycinin A1aB1b homotrimer., Adachi M, Takenaka Y, Gidamis AB, Mikami B, Utsumi S, J Mol Biol. 2001 Jan 12;305(2):291-305. PMID:11124907
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