This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ztw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:54, 1 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2ztw' size='340' side='right'caption='[[2ztw]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='2ztw' size='340' side='right'caption='[[2ztw]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2ztw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZTW FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2ztw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZTW FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEI:(2Z)-2-HYDROXY-3-(METHYLSULFANYL)PROP-2-ENOIC+ACID'>DEI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">leuB, TTHA1230 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEI:(2Z)-2-HYDROXY-3-(METHYLSULFANYL)PROP-2-ENOIC+ACID'>DEI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ztw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ztw OCA], [https://pdbe.org/2ztw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ztw RCSB], [https://www.ebi.ac.uk/pdbsum/2ztw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ztw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ztw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ztw OCA], [https://pdbe.org/2ztw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ztw RCSB], [https://www.ebi.ac.uk/pdbsum/2ztw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ztw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
+
[https://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 37: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
 
-
[[Category: 3-isopropylmalate dehydrogenase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Eguchi, T]]
+
[[Category: Thermus thermophilus]]
-
[[Category: Kumasaka, T]]
+
[[Category: Eguchi T]]
-
[[Category: Nango, E]]
+
[[Category: Kumasaka T]]
-
[[Category: Amino-acid biosynthesis]]
+
[[Category: Nango E]]
-
[[Category: Branched-chain amino acid biosynthesis]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Decarboxylating dehydrogenase]]
+
-
[[Category: Ipmdh]]
+
-
[[Category: Leucine biosynthesis]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Manganese]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nad]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

Structure of 3-isopropylmalate dehydrogenase in complex with the inhibitor and NAD+

PDB ID 2ztw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ztw"
Personal tools