Journal:Acta Cryst F:S2053230X21013455
From Proteopedia
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The structures are similar to those of BADH from ''Pseudomonas aeruginosa'' (''Pa''BADH). The co-factor binding domains of ''Bp''BADH ([[6wsb]]) and ''Pa''BADH ([[4caz]]) are well conserved (identical residues of both structures are labeled in green, while non-identical in red): | The structures are similar to those of BADH from ''Pseudomonas aeruginosa'' (''Pa''BADH). The co-factor binding domains of ''Bp''BADH ([[6wsb]]) and ''Pa''BADH ([[4caz]]) are well conserved (identical residues of both structures are labeled in green, while non-identical in red): | ||
*<scene name='89/899476/Cv/11'>Co-factor binding domain of BpBADH</scene> ([[6wsb]]). | *<scene name='89/899476/Cv/11'>Co-factor binding domain of BpBADH</scene> ([[6wsb]]). | ||
| - | *<scene name='89/899476/Cv/10'>Co-factor binding domain of PaBADH</scene> | + | *<scene name='89/899476/Cv/10'>Co-factor binding domain of PaBADH</scene> ([[4caz]]). |
| + | *<scene name='89/899476/Cv/12'>Superposition of BpBADH and PaBADH</scene> (BpBADH is colored in green, PaBADH is in olive). | ||
''Pa''BADH is inhibited by the drug disulfiram which is an approved drug. Our preliminary analysis could facilitate drug repurposing studies for melioidosis. This project is an educational collaboration between the SSGCID and Hampton University. The SSGCID consortium is directed by Dr. Peter Myler (principal investigator) and comprises many different scientists working at multiple centers towards determining the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases. Dylan K. Beard was part of a pilot Hampton University Chemistry Education and Mentorship Course-based undergraduate research (HU-ChEM CURES) funded by the NIGMS. | ''Pa''BADH is inhibited by the drug disulfiram which is an approved drug. Our preliminary analysis could facilitate drug repurposing studies for melioidosis. This project is an educational collaboration between the SSGCID and Hampton University. The SSGCID consortium is directed by Dr. Peter Myler (principal investigator) and comprises many different scientists working at multiple centers towards determining the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases. Dylan K. Beard was part of a pilot Hampton University Chemistry Education and Mentorship Course-based undergraduate research (HU-ChEM CURES) funded by the NIGMS. | ||
Revision as of 16:19, 20 December 2021
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
