1d2q
From Proteopedia
(New page: 200px<br /> <applet load="1d2q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d2q, resolution 2.8Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1d2q.gif|left|200px]]<br /> | + | [[Image:1d2q.gif|left|200px]]<br /><applet load="1d2q" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1d2q" size=" | + | |
caption="1d2q, resolution 2.8Å" /> | caption="1d2q, resolution 2.8Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN TRAIL'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN TRAIL'''<br /> | ||
==Overview== | ==Overview== | ||
| - | TRAIL is a newly identified cytokine belonging to the large tumor necrosis | + | TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of 12-16 amino acids adopts a salient loop structure penetrating into the receptor-binding site. The loop drastically alters the common receptor-binding surface of the TNF family most likely for the specific recognition of cognate partners. A structure-based mutagenesis study demonstrates a critical role of the insertion loop in the cytotoxic activity of TRAIL. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1D2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1D2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Q OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Cha, S | + | [[Category: Cha, S S.]] |
[[Category: cytokine]] | [[Category: cytokine]] | ||
[[Category: trail]] | [[Category: trail]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:12:26 2008'' |
Revision as of 10:12, 21 February 2008
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CRYSTAL STRUCTURE OF HUMAN TRAIL
Contents |
Overview
TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of 12-16 amino acids adopts a salient loop structure penetrating into the receptor-binding site. The loop drastically alters the common receptor-binding surface of the TNF family most likely for the specific recognition of cognate partners. A structure-based mutagenesis study demonstrates a critical role of the insertion loop in the cytotoxic activity of TRAIL.
Disease
Known disease associated with this structure: Squamous cell carcinoma, head and neck OMIM:[603612]
About this Structure
1D2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity., Cha SS, Kim MS, Choi YH, Sung BJ, Shin NK, Shin HC, Sung YC, Oh BH, Immunity. 1999 Aug;11(2):253-61. PMID:10485660
Page seeded by OCA on Thu Feb 21 12:12:26 2008
