1fzd

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{{STRUCTURE_1fzd| PDB=1fzd | SCENE= }}
{{STRUCTURE_1fzd| PDB=1fzd | SCENE= }}
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'''STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420'''
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===STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420===
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==Overview==
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The crystal structure of a recombinant alphaEC domain from human fibrinogen-420 has been determined at a resolution of 2.1 A. The protein, which corresponds to the carboxyl domain of the alphaE chain, was expressed in and purified from Pichia pastoris cells. Felicitously, during crystallization an amino-terminal segment was removed, apparently by a contaminating protease, allowing the 201-residue remaining parent body to crystallize. An x-ray structure was determined by molecular replacement. The electron density was clearly defined, partly as a result of averaging made possible by there being eight molecules in the asymmetric unit related by noncrystallographic symmetry (P1 space group). Virtually all of an asparagine-linked sugar cluster is present. Comparison with structures of the beta- and gamma-chain carboxyl domains of human fibrinogen revealed that the binding cleft is essentially neutral and should not bind Gly-Pro-Arg or Gly-His-Arg peptides of the sort bound by those other domains. Nonetheless, the cleft is clearly evident, and the possibility of binding a carbohydrate ligand like sialic acid has been considered.
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(as it appears on PubMed at http://www.pubmed.gov), where 9689040 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9689040}}
==About this Structure==
==About this Structure==
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[[Category: Fibrinogen-420]]
[[Category: Fibrinogen-420]]
[[Category: Glycosylated protein]]
[[Category: Glycosylated protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:56:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:10:05 2008''

Revision as of 01:10, 1 July 2008

Image:1fzd.png

Template:STRUCTURE 1fzd

STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420

Template:ABSTRACT PUBMED 9689040

About this Structure

1FZD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a recombinant alphaEC domain from human fibrinogen-420., Spraggon G, Applegate D, Everse SJ, Zhang JZ, Veerapandian L, Redman C, Doolittle RF, Grieninger G, Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9099-104. PMID:9689040

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