1fzi

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[[Image:1fzi.gif|left|200px]]
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{{Seed}}
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[[Image:1fzi.png|left|200px]]
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{{STRUCTURE_1fzi| PDB=1fzi | SCENE= }}
{{STRUCTURE_1fzi| PDB=1fzi | SCENE= }}
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'''METHANE MONOOXYGENASE HYDROXYLASE, FORM I PRESSURIZED WITH XENON GAS'''
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===METHANE MONOOXYGENASE HYDROXYLASE, FORM I PRESSURIZED WITH XENON GAS===
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==Overview==
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To investigate the role of protein cavities in facilitating movement of the substrates, methane and dioxygen, in the soluble methane monooxygenase hydroxylase (MMOH), we determined the X-ray structures of MMOH from Methylococcus capsulatus (Bath) cocrystallized with dibromomethane or iodoethane, or by using crystals pressurized with xenon gas. The halogenated alkanes bind in two cavities within the alpha-subunit that extend from one surface of the protein to the buried dinuclear iron active site. Two additional binding sites were located in the beta-subunit. Pressurization of two crystal forms of MMOH with xenon resulted in the identification of six binding sites located exclusively in the alpha-subunit. These results indicate that hydrophobic species bind preferentially in preexisting cavities in MMOH and support the hypothesis that such cavities may play a functional role in sequestering and enhancing the availability of the physiological substrates for reaction at the active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_11297413}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11297413 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11297413}}
==About this Structure==
==About this Structure==
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[[Category: Dinuclear iron center]]
[[Category: Dinuclear iron center]]
[[Category: Monooxygenase]]
[[Category: Monooxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:56:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:10:28 2008''

Revision as of 01:10, 1 July 2008

Image:1fzi.png

Template:STRUCTURE 1fzi

METHANE MONOOXYGENASE HYDROXYLASE, FORM I PRESSURIZED WITH XENON GAS

Template:ABSTRACT PUBMED 11297413

About this Structure

1FZI is a Protein complex structure of sequences from Methylococcus capsulatus. Full crystallographic information is available from OCA.

Reference

Xenon and halogenated alkanes track putative substrate binding cavities in the soluble methane monooxygenase hydroxylase., Whittington DA, Rosenzweig AC, Frederick CA, Lippard SJ, Biochemistry. 2001 Mar 27;40(12):3476-82. PMID:11297413

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