2f19

From Proteopedia

(Difference between revisions)

Current revision

THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY

Structural highlights

2f19 is a 2 chain structure with sequence from Mus musculus. This structure supersedes the now removed PDB entry 1f19. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IGKC_MOUSE

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structure of FabR19.9 from a well-characterized anti-p-azobenzenearsonate monoclonal antibody has been determined by x-ray diffraction techniques in two crystalline forms (I and II) to a resolution of 2.8 and 2.7 A, respectively. Essentially the same tertiary and quaternary structure of the Fab is observed in the two forms. The major difference resides in the intermolecular contacts, which are interpreted to favor an irreversible transition from the metastable form I to the more stable form II. The third complementarity-determining region of the heavy chain (H3) folds back over the combining site and requires rearrangement for hapten binding. This dynamic requirement on H3 is consistent with its mobility in the structure and can explain hapten binding to an otherwise inaccessible antibody combining site.

Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody.,Lascombe MB, Alzari PM, Poljak RJ, Nisonoff A Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9429-33. PMID:1409652^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lascombe MB, Alzari PM, Poljak RJ, Nisonoff A. Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9429-33. PMID:1409652

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f19"

@@ Line 3: / Line 3: @@
 <StructureSection load='2f19' size='340' side='right'caption='[[2f19]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2f19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1f19 1f19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F19 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2f19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1f19 1f19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F19 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fai|1fai]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f19 OCA], [https://pdbe.org/2f19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f19 RCSB], [https://www.ebi.ac.uk/pdbsum/2f19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f19 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 36: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Alzari, P M]]
+[[Category: Alzari PM]]
-[[Category: Lascombe, M B]]
+[[Category: Lascombe MB]]
-[[Category: Nisonoff, A]]
+[[Category: Nisonoff A]]
-[[Category: Poljak, R J]]
+[[Category: Poljak RJ]]
-[[Category: Immunoglobulin]]

2f19

From Proteopedia

Current revision

THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox