3a4k

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Current revision (14:10, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3a4k' size='340' side='right'caption='[[3a4k]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
<StructureSection load='3a4k' size='340' side='right'caption='[[3a4k]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a4k]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Haein Haein]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A4K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a4k]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A4K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2e52|2e52]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hindIIIR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 HAEIN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Type_II_site-specific_deoxyribonuclease Type II site-specific deoxyribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.4 3.1.21.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a4k OCA], [https://pdbe.org/3a4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a4k RCSB], [https://www.ebi.ac.uk/pdbsum/3a4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a4k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a4k OCA], [https://pdbe.org/3a4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a4k RCSB], [https://www.ebi.ac.uk/pdbsum/3a4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a4k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/T2D3_HAEIN T2D3_HAEIN]] Recognizes the double-stranded sequence AAGCTT and cleaves after A-1.
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[https://www.uniprot.org/uniprot/T2D3_HAEIN T2D3_HAEIN] Recognizes the double-stranded sequence AAGCTT and cleaves after A-1.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Haein]]
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[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Type II site-specific deoxyribonuclease]]
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[[Category: Sato C]]
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[[Category: Sato, C]]
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[[Category: Takasaki Y]]
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[[Category: Takasaki, Y]]
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[[Category: Tanaka I]]
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[[Category: Tanaka, I]]
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[[Category: Watanabe N]]
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[[Category: Watanabe, N]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Nuclease]]
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[[Category: Restriction system]]
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Current revision

Crystal structural analysis of HindIII restriction endonuclease in complex with cognate DNA and divalent cations at 2.17 angstrom resolution

PDB ID 3a4k

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OCA

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