GABAA receptor
From Proteopedia
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<StructureSection load='5o8f' size='340' side='right' caption='Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on [[5o8f]]) scene='89/896619/Cv/3'> | <StructureSection load='5o8f' size='340' side='right' caption='Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on [[5o8f]]) scene='89/896619/Cv/3'> | ||
| - | '''GABAA receptors''', which | + | '''GABAA receptors''', which are considered ligand-gated ion channels as the binding of GABA results in the opening of ion channels leading to the inhibition of a neuronal signal. Excitatory neurosteroids have excitatory effects on neurotransmission. They act as potent negative allosteric modulators of the GABAA receptor. Major examples include the pregnanes pregnenolone sulfate (PS), epipregnanolone, and isopregnanolone (sepranolone). |
*<scene name='89/896619/Cv/5'>Pregnenolone alone</scene>. | *<scene name='89/896619/Cv/5'>Pregnenolone alone</scene>. | ||
*<scene name='89/896619/Cv/4'>Pregnanolone binds beta3-alpha5 GABAA receptor</scene> ([[5o8f]]). | *<scene name='89/896619/Cv/4'>Pregnanolone binds beta3-alpha5 GABAA receptor</scene> ([[5o8f]]). | ||
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</StructureSection> | </StructureSection> | ||
==GABAA receptor 3D structures== | ==GABAA receptor 3D structures== | ||
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| + | See [[GABA receptor 3D structures]] | ||
*[[6d1s]] – hGABAA subunit α-1 - human<br /> | *[[6d1s]] – hGABAA subunit α-1 - human<br /> | ||
Revision as of 09:15, 19 January 2022
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GABAA receptor 3D structures
See GABA receptor 3D structures
- 6d1s – hGABAA subunit α-1 - human
- 4cof – hGABAA subunit β-3
- 7a5v – hGABAA subunit β-3 + megabody – Cryo EM
- 6i53, 6hup, 6huo, 6huk, 6huj, 6hug – hGABAA subunits α-1+β-3+γ-2 + megabody – Cryo EM
- 6d6u, 6d6t – hGABAA subunits α-1+β-3+γ-2 + antibody + GABA + antagonist – Cryo EM
- 6x3s, 6x3t, 6x3u, 6x3v, 6x3w, 6x3x, 6x40 – hGABAA subunits α-1+β-2+γ-2 + antibody + GABA + antagonist – Cryo EM
- 6a96 – hGABAA subunits β-3 +α-5 + nanobody + GABA – Cryo EM
- 6cdu – hGABAA subunit α-1 + alphaxalone
- 6hsn – rGABAA subunit α-3 + gephyrin + ADP - rat
- 6dw1, 6dw0 – rGABAA subunits α-1+β-1+γ-2 + GABA – Cryo EM
- 7cdb – GABAA subunit γ-2 + GABA receptor-associated protein-like 1 - mouse
