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1g0d

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{{STRUCTURE_1g0d| PDB=1g0d | SCENE= }}
{{STRUCTURE_1g0d| PDB=1g0d | SCENE= }}
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'''CRYSTAL STRUCTURE OF RED SEA BREAM TRANSGLUTAMINASE'''
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===CRYSTAL STRUCTURE OF RED SEA BREAM TRANSGLUTAMINASE===
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==Overview==
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The crystal structure of the tissue-type transglutaminase from red sea bream liver (fish-derived transglutaminase, FTG) has been determined at 2.5-A resolution using the molecular replacement method, based on the crystal structure of human blood coagulation factor XIII, which is a transglutaminase zymogen. The model contains 666 residues of a total of 695 residues, 382 water molecules, and 1 sulfate ion. FTG consists of four domains, and its overall and active site structures are similar to those of human factor XIII. However, significant structural differences are observed in both the acyl donor and acyl acceptor binding sites, which account for the difference in substrate preferences. The active site of the enzyme is inaccessible to the solvent, because the catalytic Cys-272 hydrogen-bonds to Tyr-515, which is thought to be displaced upon acyl donor binding to FTG. It is postulated that the binding of an inappropriate substrate to FTG would lead to inactivation of the enzyme because of the formation of a new disulfide bridge between Cys-272 and the adjacent Cys-333 immediately after the displacement of Tyr-515. Considering the mutational studies previously reported on the tissue-type transglutaminases, we propose that Cys-333 and Tyr-515 are important in strictly controlling the enzymatic activity of FTG.
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(as it appears on PubMed at http://www.pubmed.gov), where 11080504 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11080504}}
==About this Structure==
==About this Structure==
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[[Category: Yokoyama, K.]]
[[Category: Yokoyama, K.]]
[[Category: Tissue transglutaminase,acyltransferase]]
[[Category: Tissue transglutaminase,acyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:58:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:12:41 2008''

Revision as of 01:12, 1 July 2008

Image:1g0d.png

Template:STRUCTURE 1g0d

CRYSTAL STRUCTURE OF RED SEA BREAM TRANSGLUTAMINASE

Template:ABSTRACT PUBMED 11080504

About this Structure

1G0D is a Single protein structure of sequence from Pagrus major. Full crystallographic information is available from OCA.

Reference

Crystal structure of red sea bream transglutaminase., Noguchi K, Ishikawa K, Yokoyama Ki, Ohtsuka T, Nio N, Suzuki E, J Biol Chem. 2001 Apr 13;276(15):12055-9. Epub 2000 Nov 15. PMID:11080504

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