7t5f
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10== |
| - | <StructureSection load='7t5f' size='340' side='right'caption='[[7t5f]]' scene=''> | + | <StructureSection load='7t5f' size='340' side='right'caption='[[7t5f]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t5f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae Camelidae] and [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5F FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5f OCA], [https://pdbe.org/7t5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5f RCSB], [https://www.ebi.ac.uk/pdbsum/7t5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5f ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5f OCA], [https://pdbe.org/7t5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5f RCSB], [https://www.ebi.ac.uk/pdbsum/7t5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Camelidae]] | ||
| + | [[Category: Clostridium botulinum]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Jin R]] |
| + | [[Category: Lam K-H]] | ||
Revision as of 07:21, 3 April 2024
Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10
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