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2g70

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Current revision (08:47, 25 October 2023) (edit) (undo)
 
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<StructureSection load='2g70' size='340' side='right'caption='[[2g70]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2g70' size='340' side='right'caption='[[2g70]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2g70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G70 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2g70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G70 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNT:[(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL'>HNT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hnn|1hnn]], [[1nji|1nji]], [[1n7j|1n7j]], [[1yz3|1yz3]], [[2an3|2an3]], [[2an4|2an4]], [[2g71|2g71]], [[2g72|2g72]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNT:[(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL'>HNT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g70 OCA], [https://pdbe.org/2g70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g70 RCSB], [https://www.ebi.ac.uk/pdbsum/2g70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g70 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g70 OCA], [https://pdbe.org/2g70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g70 RCSB], [https://www.ebi.ac.uk/pdbsum/2g70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g70 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.
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[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phenylethanolamine N-methyltransferase]]
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[[Category: Gee CL]]
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[[Category: Gee, C L]]
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[[Category: Martin JL]]
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[[Category: Martin, J L]]
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[[Category: Tyndall JDA]]
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[[Category: Tyndall, J D.A]]
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[[Category: Methyltransferase]]
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[[Category: Transferase]]
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Current revision

Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)

PDB ID 2g70

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OCA

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