3alz

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Current revision (15:48, 4 October 2023) (edit) (undo)
 
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<StructureSection load='3alz' size='340' side='right'caption='[[3alz]], [[Resolution|resolution]] 4.51&Aring;' scene=''>
<StructureSection load='3alz' size='340' side='right'caption='[[3alz]], [[Resolution|resolution]] 4.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3alz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cotton-top_tamarin Cotton-top tamarin] and [https://en.wikipedia.org/wiki/Measf Measf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ALZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3alz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_virus_strain_Edmonston-B Measles virus strain Edmonston-B] and [https://en.wikipedia.org/wiki/Saguinus_oedipus Saguinus oedipus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ALZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.515&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3alw|3alw]], [[3alx|3alx]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hemagglutinin ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70146 MEASF]), SLAM (CD150) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9490 Cotton-top tamarin])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3alz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alz OCA], [https://pdbe.org/3alz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3alz RCSB], [https://www.ebi.ac.uk/pdbsum/3alz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3alz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3alz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alz OCA], [https://pdbe.org/3alz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3alz RCSB], [https://www.ebi.ac.uk/pdbsum/3alz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3alz ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cotton-top tamarin]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Measf]]
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[[Category: Measles virus strain Edmonston-B]]
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[[Category: Hashiguchi, T]]
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[[Category: Saguinus oedipus]]
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[[Category: Kamishikiryo, J]]
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[[Category: Hashiguchi T]]
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[[Category: Kubota, M]]
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[[Category: Kamishikiryo J]]
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[[Category: Maenaka, K]]
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[[Category: Kubota M]]
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[[Category: Maita, N]]
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[[Category: Maenaka K]]
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[[Category: Ose, T]]
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[[Category: Maita N]]
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[[Category: Yanagi, Y]]
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[[Category: Ose T]]
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[[Category: Beta-sandwich]]
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[[Category: Yanagi Y]]
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[[Category: Immunoglobulin fold]]
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[[Category: Six-bladed beta-propeller fold]]
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[[Category: Viral protein-membrane protein complex]]
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[[Category: Viral protein-receptor complex]]
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Current revision

Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I)

PDB ID 3alz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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