We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1g1o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1g1o.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1g1o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1g1o| PDB=1g1o | SCENE= }}
{{STRUCTURE_1g1o| PDB=1g1o | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S'''
+
===CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S===
-
==Overview==
+
<!--
-
Transthyretin is a tetrameric plasma protein associated with two forms of amyloid disease. The structure of the highly amyloidogenic transthyretin triple mutant TTRG53S/E54D/L55S determined at 2.3 A resolution reveals a novel conformation: the beta-slip. A three-residue shift in beta strand D places Leu-58 at the position normally occupied by Leu-55 now mutated to serine. The beta-slip is best defined in two of the four monomers, where it makes new protein-protein interactions to an area normally involved in complex formation with retinol-binding protein. This interaction creates unique packing arrangements, where two protein helices combine to form a double helix in agreement with fiber diffraction and electron microscopy data. Based on these findings, a novel model for transthyretin amyloid formation is presented.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11106758}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11106758 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11106758}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Beta-slip]]
[[Category: Beta-slip]]
[[Category: Greek key]]
[[Category: Greek key]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:01:21 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:16:26 2008''

Revision as of 01:16, 1 July 2008

Image:1g1o.png

Template:STRUCTURE 1g1o

CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S

Template:ABSTRACT PUBMED 11106758

About this Structure

1G1O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The beta-slip: a novel concept in transthyretin amyloidosis., Eneqvist T, Andersson K, Olofsson A, Lundgren E, Sauer-Eriksson AE, Mol Cell. 2000 Nov;6(5):1207-18. PMID:11106758

Page seeded by OCA on Tue Jul 1 04:16:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g1o"
Personal tools