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7w6s
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of human KChIP2-Kv4.3 complex== | |
| - | + | <StructureSection load='7w6s' size='340' side='right'caption='[[7w6s]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7w6s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6s OCA], [https://pdbe.org/7w6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6s RCSB], [https://www.ebi.ac.uk/pdbsum/7w6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6s ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KCIP2_HUMAN KCIP2_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).[UniProtKB:Q9JJ69]<ref>PMID:10676964</ref> <ref>PMID:11287421</ref> <ref>PMID:11684073</ref> <ref>PMID:12297301</ref> <ref>PMID:12829703</ref> <ref>PMID:14623880</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Guo JT]] | ||
| + | [[Category: Ma DM]] | ||
Current revision
CryoEM structure of human KChIP2-Kv4.3 complex
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