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1g28

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{{STRUCTURE_1g28| PDB=1g28 | SCENE= }}
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'''STRUCTURE OF A FLAVIN-BINDING DOMAIN, LOV2, FROM THE CHIMERIC PHYTOCHROME/PHOTOTROPIN PHOTORECEPTOR PHY3'''
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===STRUCTURE OF A FLAVIN-BINDING DOMAIN, LOV2, FROM THE CHIMERIC PHYTOCHROME/PHOTOTROPIN PHOTORECEPTOR PHY3===
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==Overview==
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Phototropin, a major blue-light receptor for phototropism in seed plants, exhibits blue-light-dependent autophosphorylation and contains two light, oxygen, or voltage (LOV) domains and a serine/threonine kinase domain. The LOV domains share homology with the PER-ARNT-SIM (PAS) superfamily, a diverse group of sensor proteins. Each LOV domain noncovalently binds a single FMN molecule and exhibits reversible photochemistry in vitro when expressed separately or in tandem. We have determined the crystal structure of the LOV2 domain from the phototropin segment of the chimeric fern photoreceptor phy3 to 2.7-A resolution. The structure constitutes an FMN-binding fold that reveals how the flavin cofactor is embedded in the protein. The single LOV2 cysteine residue is located 4.2 A from flavin atom C(4a), consistent with a model in which absorption of blue light induces formation of a covalent cysteinyl-C(4a) adduct. Residues that interact with FMN in the phototropin segment of the chimeric fern photoreceptor (phy3) LOV2 are conserved in LOV domains from phototropin of other plant species and from three proteins involved in the regulation of circadian rhythms in Arabidopsis and Neurospora. This conservation suggests that these domains exhibit the same overall fold and share a common mechanism for flavin binding and light-induced signaling.
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{{ABSTRACT_PUBMED_11248020}}
==About this Structure==
==About this Structure==
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[[Category: Photoreceptor]]
[[Category: Photoreceptor]]
[[Category: Phototropin]]
[[Category: Phototropin]]
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Revision as of 01:17, 1 July 2008

Image:1g28.png


PDB ID 1g28

Drag the structure with the mouse to rotate
1g28, resolution 2.73Å ()
Ligands:
Gene: PHY3 (Adiantum capillus-veneris)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF A FLAVIN-BINDING DOMAIN, LOV2, FROM THE CHIMERIC PHYTOCHROME/PHOTOTROPIN PHOTORECEPTOR PHY3

Template:ABSTRACT PUBMED 11248020

About this Structure

1G28 is a Single protein structure of sequence from Eukaryota. Full crystallographic information is available from OCA.

Reference

Structure of a flavin-binding plant photoreceptor domain: insights into light-mediated signal transduction., Crosson S, Moffat K, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):2995-3000. Epub 2001 Feb 27. PMID:11248020

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