1fm5

<table><tr><td colspan='2'>[[1fm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FM5 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fm5 OCA], [https://pdbe.org/1fm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fm5 RCSB], [https://www.ebi.ac.uk/pdbsum/1fm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fm5 ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/CD69_HUMAN CD69_HUMAN]] Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

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== Publication Abstract from PubMed ==

CD69 is a widely expressed type II transmembrane glycoprotein related to the C-type animal lectins that exhibits regulated expression on a variety of cells of the hematopoietic lineage, including neutrophils, monocytes, T cells, B cells, natural killer (NK) cells, and platelets. Activation of T lymphocytes results in the induced expression of CD69 at the cell surface. In addition, cross-linking of CD69 by specific antibodies leads to the activation of cells bearing this receptor and to the induction of effector functions. However, the physiological ligand of CD69 is unknown. We report here the X-ray crystal structure of the extracellular C-type lectin-like domain (CTLD) of human CD69 at 2.27 A resolution. Recombinant CD69 was expressed in bacterial inclusion bodies and folded in vitro. The protein, which exists as a disulfide-linked homodimer on the cell surface, crystallizes as a symmetrical dimer, similar to those formed by the related NK cell receptors Ly49A and CD94. The structure reveals conservation of the C-type lectin-like fold, including preservation of the two alpha-helical regions found in Ly49A and mannose-binding protein (MBP). However, only one of the nine residues coordinated to Ca(2+) in MBP is conserved in CD69 and no bound Ca(2+) is evident in the crystal structure. Surprisingly, electron density suggestive of a puckered six-membered ring was discovered at a site structurally analogous to the ligand-binding sites of MBP and Ly49A. This sugar-like density may represent, or mimic, part of the natural ligand recognized by CD69.

Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells.,Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA Biochemistry. 2000 Dec 5;39(48):14779-86. PMID:11101293<ref>PMID:11101293</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Human]]

[[Category: Margulies, D H]]

[[Category: Mariuzza, R A]]

[[Category: Natarajan, K]]

[[Category: Sawicki, M W]]

[[Category: Natural killer cell receptor]]