2hfo
From Proteopedia
(Difference between revisions)
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<StructureSection load='2hfo' size='340' side='right'caption='[[2hfo]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2hfo' size='340' side='right'caption='[[2hfo]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2hfo]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2hfo]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFO FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfo OCA], [https://pdbe.org/2hfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfo RCSB], [https://www.ebi.ac.uk/pdbsum/2hfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfo OCA], [https://pdbe.org/2hfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfo RCSB], [https://www.ebi.ac.uk/pdbsum/2hfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P74295_SYNY3 P74295_SYNY3] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hfo ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hfo ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Crystal structures of the Synechocystis BLUF phototaxis photoreceptor Slr1694 have been determined in two crystal forms, a monoclinic form at 1.8 A resolution and an orthorhombic form at 2.1 A resolution. In both forms, the photoreceptor is comprised of two pentamer rings stacked face to face. Twenty total subunits in the two asymmetric units of these crystal forms display three distinct tertiary structures that differ in the length of the fifth beta-strand and in the orientation of Trp91, a conserved Trp residue near the FMN chromophore. Fluorescence spectroscopic analysis on Slr1694 in solution is consistent with motion of Trp91 from a hydrophobic environment in the dark state to a more hydrophilic environment in the light-excited state. Mutational analysis indicates that movement of Trp91 is dependent on the occupancy of the hydrophobic Trp binding pocket with a nearby Met. These different tertiary structures may be associated with absorption changes in the blue region of the spectrum. | ||
| - | |||
| - | Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling.,Yuan H, Anderson S, Masuda S, Dragnea V, Moffat K, Bauer C Biochemistry. 2006 Oct 24;45(42):12687-94. PMID:17042486<ref>PMID:17042486</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2hfo" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Anderson | + | [[Category: Synechocystis sp. PCC 6803]] |
| - | [[Category: Bauer | + | [[Category: Anderson S]] |
| - | [[Category: Dragnea | + | [[Category: Bauer CE]] |
| - | [[Category: Masuda | + | [[Category: Dragnea V]] |
| - | [[Category: Moffat | + | [[Category: Masuda S]] |
| - | [[Category: Yuan | + | [[Category: Moffat K]] |
| - | + | [[Category: Yuan H]] | |
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Current revision
Crystal Structures of the Synechocystis Photoreceptor Slr1694 Reveal Distinct Structural States Related to Signaling
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