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3b7l

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Human farnesyl diphosphate synthase complexed with MG and minodronate

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@@ Line 3: / Line 3: @@
 <StructureSection load='3b7l' size='340' side='right'caption='[[3b7l]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3b7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7L FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3b7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7L FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0N:(1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC+ACID)'>M0N</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yq7|1yq7]], [[2qis|2qis]], [[1zw5|1zw5]], [[1yv5|1yv5]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0N:(1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC+ACID)'>M0N</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7l OCA], [https://pdbe.org/3b7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7l RCSB], [https://www.ebi.ac.uk/pdbsum/3b7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7l ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: Delft, F von]]
+[[Category: Dunford JE]]
-[[Category: Dunford, J E]]
+[[Category: Ebetino FH]]
-[[Category: Ebetino, F H]]
+[[Category: Edwards AM]]
-[[Category: Edwards, A M]]
+[[Category: Guo K]]
-[[Category: Guo, K]]
+[[Category: Kavanagh KL]]
-[[Category: Kavanagh, K L]]
+[[Category: Oppermann U]]
-[[Category: Oppermann, U]]
+[[Category: Pike ACW]]
-[[Category: Pike, A C.W]]
+[[Category: Pilka ES]]
-[[Category: Pilka, E S]]
+[[Category: Russell RGG]]
-[[Category: Russell, R G.G]]
+[[Category: Von Delft F]]
-[[Category: Structural genomic]]
-[[Category: Bisphosphonate]]
-[[Category: Cholesterol biosynthesis]]
-[[Category: Cholesterol synthesis]]
-[[Category: Host-virus interaction]]
-[[Category: Isoprene biosynthesis]]
-[[Category: Isoprenoid pathway]]
-[[Category: Lipid synthesis]]
-[[Category: Sgc]]
-[[Category: Steroid biosynthesis]]
-[[Category: Sterol biosynthesis]]
-[[Category: Transferase]]

3b7l

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Current revision

Human farnesyl diphosphate synthase complexed with MG and minodronate

Structural highlights

Function

Evolutionary Conservation

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