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1g37

From Proteopedia

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[[Image:1g37.gif|left|200px]]
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{{STRUCTURE_1g37| PDB=1g37 | SCENE= }}
{{STRUCTURE_1g37| PDB=1g37 | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE'''
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===CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE===
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==Overview==
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Bicyclic piperazinone based thrombin inhibitors of general structure 2 were prepared and evaluated in vitro and in vivo. These inhibitors, having in common an electrophilic basic trans-cyclohexylamine P1 residue, displayed high thrombin affinity, high selectivity against trypsin and good in vivo efficacy in the rat arterial thrombosis model.
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(as it appears on PubMed at http://www.pubmed.gov), where 11212093 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11212093}}
==About this Structure==
==About this Structure==
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[[Category: Protease]]
[[Category: Protease]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:04:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:20:43 2008''

Revision as of 01:20, 1 July 2008

Template:STRUCTURE 1g37

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE

Template:ABSTRACT PUBMED 11212093

About this Structure

1G37 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors., Bachand B, Tarazi M, St-Denis Y, Edmunds JJ, Winocour PD, Leblond L, Siddiqui MA, Bioorg Med Chem Lett. 2001 Feb 12;11(3):287-90. PMID:11212093

Page seeded by OCA on Tue Jul 1 04:20:43 2008

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