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7sag
From Proteopedia
(Difference between revisions)
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<StructureSection load='7sag' size='340' side='right'caption='[[7sag]]' scene=''> | <StructureSection load='7sag' size='340' side='right'caption='[[7sag]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7sag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geodia_barretti Geodia barretti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SAG FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sag OCA], [https://pdbe.org/7sag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sag RCSB], [https://www.ebi.ac.uk/pdbsum/7sag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sag ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sag OCA], [https://pdbe.org/7sag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sag RCSB], [https://www.ebi.ac.uk/pdbsum/7sag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sag ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A384E130_9METZ A0A384E130_9METZ] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Natural product discovery by isolation and structure elucidation is a laborious task often requiring ample quantities of biological starting material and frequently resulting in the rediscovery of previously known compounds. However, peptides are a compound class amenable to an alternative genomic, transcriptomic, and in silico discovery route by similarity searches of known peptide sequences against sequencing data. Based on the sequences of barrettides A and B, we identified five new barrettide sequences (barrettides C-G) predicted from the North Atlantic deep-sea demosponge Geodia barretti (Geodiidae). We synthesized, folded, and investigated one of the newly described barrettides, barrettide C (NVVPCFCVEDETSGAKTCIPDNCDASRGTNP, disulfide connectivity I-IV, II-III). Co-elution experiments of synthetic and sponge-derived barrettide C confirmed its native conformation. NMR spectroscopy and the anti-biofouling activity on larval settlement of the bay barnacle Amphibalanus improvisus (IC50 0.64 muM) show that barrettide C is highly similar to barrettides A and B in both structure and function. Several lines of evidence suggest that barrettides are produced by the sponge itself and not one of its microbial symbionts. | ||
| + | |||
| + | Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti.,Steffen K, Laborde Q, Gunasekera S, Payne CD, Rosengren KJ, Riesgo A, Goransson U, Cardenas P J Nat Prod. 2021 Dec 24;84(12):3138-3146. doi: 10.1021/acs.jnatprod.1c00938. Epub, 2021 Dec 7. PMID:34874154<ref>PMID:34874154</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7sag" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Geodia barretti]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Payne CD]] | [[Category: Payne CD]] | ||
[[Category: Rosengren KJ]] | [[Category: Rosengren KJ]] | ||
Current revision
Solution NMR structure of barrettide C
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