1g3x

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{{STRUCTURE_1g3x| PDB=1g3x | SCENE= }}
{{STRUCTURE_1g3x| PDB=1g3x | SCENE= }}
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'''INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER'''
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===INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER===
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==Overview==
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We present the crystal structure of an acridine drug derivatized at carbon 9, [N(alpha)-(9-acridinoyl)-tetraarginine], intercalated within the dodecamer [d(CGCGAATTCGCG)](2). The presence of a lateral chain at the central carbon 9 atom differentiates this compound from most acridine drugs hitherto studied, which are usually derivatized at carbon 4. The DNA:drug interaction we observe differs from that observed in previous studies, which primarily involves shorter, mainly hexameric sequences, in two important regards: the acridine intercalates within an AA/TT base step, rather than within a CG/CG base step; and the binding site is located at the center of the sequence, rather than at one end of the duplex. In addition, we observe a novel crystal packing arrangement, with six dodecamer duplexes and seven hydrated magnesium ions in the asymmetric unit of a large (66.5 x 68.4 x 77.4 A(3)) unit cell in space group P2(1)2(1)2(1). The duplexes are organized in layers parallel to the ab plane, with consecutive layers crossing each other at right angles.
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{{ABSTRACT_PUBMED_12135355}}
==About this Structure==
==About this Structure==
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[[Category: Mg+2 ion]]
[[Category: Mg+2 ion]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:06:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:22:39 2008''

Revision as of 01:22, 1 July 2008

Image:1g3x.png

Template:STRUCTURE 1g3x

INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER

Template:ABSTRACT PUBMED 12135355

About this Structure

Full crystallographic information is available from OCA.

Reference

Intercalation of an acridine-peptide drug in an AA/TT base step in the crystal structure of [d(CGCGAATTCGCG)](2) with six duplexes and seven Mg(2+) ions in the asymmetric unit., Malinina L, Soler-Lopez M, Aymami J, Subirana JA, Biochemistry. 2002 Jul 30;41(30):9341-8. PMID:12135355

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