2i28

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==Solution Structure of alpha-Conotoxin BuIA==
==Solution Structure of alpha-Conotoxin BuIA==
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<StructureSection load='2i28' size='340' side='right'caption='[[2i28]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2i28' size='340' side='right'caption='[[2i28]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2i28]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I28 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2i28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_bullatus Conus bullatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I28 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i28 OCA], [https://pdbe.org/2i28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i28 RCSB], [https://www.ebi.ac.uk/pdbsum/2i28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i28 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i28 OCA], [https://pdbe.org/2i28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i28 RCSB], [https://www.ebi.ac.uk/pdbsum/2i28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i28 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CA1A_CONBU CA1A_CONBU]] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs.
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[https://www.uniprot.org/uniprot/CA1A_CONBU CA1A_CONBU] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Conus bullatus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chi, S W]]
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[[Category: Chi S-W]]
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[[Category: Han, K H]]
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[[Category: Han K-H]]
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[[Category: Kim, D H]]
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[[Category: Kim D-H]]
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[[Category: McIntosh, J M]]
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[[Category: McIntosh JM]]
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[[Category: Olivera, B M]]
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[[Category: Olivera BM]]
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[[Category: Alpha-helix]]
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[[Category: Beta-turn]]
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[[Category: C-terminal amidation]]
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[[Category: Toxin]]
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[[Category: Two disulfide bond]]
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Revision as of 16:38, 13 December 2023

Solution Structure of alpha-Conotoxin BuIA

PDB ID 2i28

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