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2iuu

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Current revision (09:29, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2iuu' size='340' side='right'caption='[[2iuu]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='2iuu' size='340' side='right'caption='[[2iuu]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2iuu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2iuu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ius|2ius]], [[2iut|2iut]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iuu OCA], [https://pdbe.org/2iuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iuu RCSB], [https://www.ebi.ac.uk/pdbsum/2iuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iuu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iuu OCA], [https://pdbe.org/2iuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iuu RCSB], [https://www.ebi.ac.uk/pdbsum/2iuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iuu ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FTSK_PSEAE FTSK_PSEAE] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (Probable).<ref>PMID:16916635</ref> <ref>PMID:18722176</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lowe, J]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Massey, T H]]
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[[Category: Lowe J]]
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[[Category: Mercogliano, C P]]
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[[Category: Massey TH]]
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[[Category: Sherratt, D J]]
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[[Category: Mercogliano CP]]
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[[Category: Yates, J]]
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[[Category: Sherratt DJ]]
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[[Category: Aaa atpase]]
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[[Category: Yates J]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Chromosome partition]]
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[[Category: Divisome]]
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[[Category: Dna translocation]]
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[[Category: Dna-binding]]
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[[Category: Hexameric ring]]
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[[Category: Inner membrane]]
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[[Category: Kop]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Transmembrane]]
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Current revision

P. aeruginosa FtsK motor domain, hexamer

PDB ID 2iuu

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