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2xkx

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Current revision (18:15, 18 October 2023) (edit) (undo)
 
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<SX load='2xkx' size='340' side='right' viewer='molstar' caption='[[2xkx]], [[Resolution|resolution]] 22.90&Aring;' scene=''>
<SX load='2xkx' size='340' side='right' viewer='molstar' caption='[[2xkx]], [[Resolution|resolution]] 22.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKX FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tq3|1tq3]], [[1rgr|1rgr]], [[1iu2|1iu2]], [[1jxm|1jxm]], [[1kjw|1kjw]], [[1tp3|1tp3]], [[1be9|1be9]], [[1bfe|1bfe]], [[1qlc|1qlc]], [[1iu0|1iu0]], [[1jxo|1jxo]], [[1tp5|1tp5]], [[2xky|2xky]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy , Hybrid , X-ray solution scattering, [[Resolution|Resolution]] 22.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkx OCA], [https://pdbe.org/2xkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkx RCSB], [https://www.ebi.ac.uk/pdbsum/2xkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkx OCA], [https://pdbe.org/2xkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkx RCSB], [https://www.ebi.ac.uk/pdbsum/2xkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
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[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2xkx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2xkx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Postsynaptic density protein|Postsynaptic density protein]]
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Collins, R F]]
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[[Category: Rattus norvegicus]]
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[[Category: Fomina, S]]
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[[Category: Collins RF]]
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[[Category: Golovanova, M]]
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[[Category: Fomina S]]
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[[Category: Grossmann, J G]]
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[[Category: Golovanova M]]
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[[Category: Howard, T D]]
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[[Category: Grossmann JG]]
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[[Category: Leyland, M L]]
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[[Category: Howard TD]]
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[[Category: Prince, S M]]
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[[Category: Leyland ML]]
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[[Category: Ryan, L O]]
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[[Category: O'Ryan L]]
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[[Category: Sleator, O K]]
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[[Category: Prince SM]]
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[[Category: Membrane associated guanylate kinase]]
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[[Category: Sleator OK]]
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[[Category: Scaffold protein]]
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[[Category: Structural protein]]
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Current revision

Single particle analysis of PSD-95 in negative stain

2xkx, resolution 22.90Å

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