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2y7c

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Current revision (18:17, 18 October 2023) (edit) (undo)
 
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<SX load='2y7c' size='340' side='right' viewer='molstar' caption='[[2y7c]], [[Resolution|resolution]] 18.00&Aring;' scene=''>
<SX load='2y7c' size='340' side='right' viewer='molstar' caption='[[2y7c]], [[Resolution|resolution]] 18.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y7c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpt7 Bpt7] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y7c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7C FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s7z|1s7z]], [[2y7h|2y7h]], [[2ar0|2ar0]], [[1yf2|1yf2]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 18&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Type_I_site-specific_deoxyribonuclease Type I site-specific deoxyribonuclease], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.3 3.1.21.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7c OCA], [https://pdbe.org/2y7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7c RCSB], [https://www.ebi.ac.uk/pdbsum/2y7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7c OCA], [https://pdbe.org/2y7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7c RCSB], [https://www.ebi.ac.uk/pdbsum/2y7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/T1MK_ECOLI T1MK_ECOLI]] The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'.
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[https://www.uniprot.org/uniprot/T1SK_ECOLI T1SK_ECOLI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
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[[Category: Bpt7]]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Escherichia phage T7]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Type I site-specific deoxyribonuclease]]
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[[Category: Bujnicki JM]]
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[[Category: Bujnicki, J M]]
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[[Category: Cooper LP]]
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[[Category: Cooper, L P]]
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[[Category: Dryden DTF]]
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[[Category: Dryden, D T.F]]
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[[Category: Kennaway CK]]
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[[Category: Kennaway, C K]]
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[[Category: Obarska-Kosinska A]]
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[[Category: Obarska-Kosinska, A]]
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[[Category: Trinick J]]
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[[Category: Trinick, J]]
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[[Category: Tuszynska I]]
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[[Category: Tuszynska, I]]
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[[Category: White JH]]
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[[Category: White, J H]]
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[[Category: Transferase]]
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Current revision

Atomic model of the Ocr-bound methylase complex from the Type I restriction-modification enzyme EcoKI (M2S1). Based on fitting into EM map 1534.

2y7c, resolution 18.00Å

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