Undecaprenyl pyrophosphate synthase

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Line 28: Line 28:
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />
**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />
 +
**[[7jli]] – BsUPP – ''Bacillus subtilis''<br />
*Undecaprenyl pyrophosphate synthase complexes
*Undecaprenyl pyrophosphate synthase complexes
Line 51: Line 52:
**[[5xk9]] – StUPP + GSPP + DMAPP <br />
**[[5xk9]] – StUPP + GSPP + DMAPP <br />
**[[6szg]], [[6szh]] - AbUPP + inhibitor<br />
**[[6szg]], [[6szh]] - AbUPP + inhibitor<br />
 +
**[[7jljj]], [[7jlm]], [[7jlr]] – BsUPP + inhibitor <br />
}}
}}

Revision as of 08:49, 20 June 2022

Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07).

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3D structures of undecaprenyl pyrophosphate synthase

Updated on 20-June-2022

References

  1. Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
  2. Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
  3. Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200

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Michal Harel, Alexander Berchansky

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