1g5h

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[[Image:1g5h.gif|left|200px]]
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{{Seed}}
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[[Image:1g5h.png|left|200px]]
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{{STRUCTURE_1g5h| PDB=1g5h | SCENE= }}
{{STRUCTURE_1g5h| PDB=1g5h | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ACCESSORY SUBUNIT OF MURINE MITOCHONDRIAL POLYMERASE GAMMA'''
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===CRYSTAL STRUCTURE OF THE ACCESSORY SUBUNIT OF MURINE MITOCHONDRIAL POLYMERASE GAMMA===
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==Overview==
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Polymerase gamma, which replicates and repairs mitochondrial DNA, requires the Pol gamma B subunit for processivity. We determined the crystal structure of mouse Pol gamma B, a core component of the mitochondrial replication machinery. Pol gamma B shows high similarity to glycyl-tRNA synthetase and dimerizes through an unusual intermolecular four-helix bundle. A human Pol gamma B mutant lacking the four-helix bundle failed to dimerize in solution or to stimulate the catalytic subunit Pol gamma A, but retained the ability to bind with Pol gamma A to a primer-template construct, indicating that the functional holoenzyme contains two Pol gamma B molecules. Other mutants retained stimulatory activity but lost the ability to bind folded ssDNA. These results suggest that the Pol gamma B dimer contains distinct sites for Pol gamma A binding, dimerization, and DNA binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 11172710 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11172710}}
==About this Structure==
==About this Structure==
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[[Category: Theis, K.]]
[[Category: Theis, K.]]
[[Category: Intermolecular four helix bundle]]
[[Category: Intermolecular four helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:09:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:27:48 2008''

Revision as of 01:27, 1 July 2008

Image:1g5h.png

Template:STRUCTURE 1g5h

CRYSTAL STRUCTURE OF THE ACCESSORY SUBUNIT OF MURINE MITOCHONDRIAL POLYMERASE GAMMA

Template:ABSTRACT PUBMED 11172710

About this Structure

1G5H is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer., Carrodeguas JA, Theis K, Bogenhagen DF, Kisker C, Mol Cell. 2001 Jan;7(1):43-54. PMID:11172710

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