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1g5j

From Proteopedia

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[[Image:1g5j.gif|left|200px]]
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{{Seed}}
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[[Image:1g5j.png|left|200px]]
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{{STRUCTURE_1g5j| PDB=1g5j | SCENE= }}
{{STRUCTURE_1g5j| PDB=1g5j | SCENE= }}
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'''COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD'''
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===COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD===
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==Overview==
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The three-dimensional structure of the anti-apoptotic protein Bcl-xL complexed to a 25-residue peptide from the death promoting region of Bad was determined using NMR spectroscopy. Although the overall structure is similar to Bcl-xL bound to a 16-residue peptide from the Bak protein (Sattler et al., 1997), the Bad peptide forms additional interactions with Bcl-xL. However, based upon site-directed mutagenesis experiments, these additional contacts do not account for the increased affinity of the Bad 25-mer for Bcl-xL compared to the Bad 16-mer. Rather, the increased helix propensity of the Bad 25-mer is primarily responsible for its greater affinity for Bcl-xL. Based on this observation, a pair of 16-residue peptides were designed and synthesized that were predicted to have a high helix propensity while maintaining the interactions important for complexation with Bcl-xL. Both peptides showed an increase in helix propensity compared to the wild-type and exhibited an enhanced affinity for Bcl-xL.
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The line below this paragraph, {{ABSTRACT_PUBMED_11206074}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11206074 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11206074}}
==About this Structure==
==About this Structure==
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1G5J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5J OCA].
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1G5J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5J OCA].
==Reference==
==Reference==
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[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Complex]]
[[Category: Complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:09:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:27:54 2008''

Revision as of 01:28, 1 July 2008

Image:1g5j.png

Template:STRUCTURE 1g5j

COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD

Template:ABSTRACT PUBMED 11206074

About this Structure

1G5J is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies., Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW, Protein Sci. 2000 Dec;9(12):2528-34. PMID:11206074

Page seeded by OCA on Tue Jul 1 04:27:54 2008

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