2j8q
From Proteopedia
(Difference between revisions)
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<StructureSection load='2j8q' size='340' side='right'caption='[[2j8q]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2j8q' size='340' side='right'caption='[[2j8q]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2j8q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2j8q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8Q FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8q OCA], [https://pdbe.org/2j8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8q RCSB], [https://www.ebi.ac.uk/pdbsum/2j8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8q ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8q OCA], [https://pdbe.org/2j8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8q RCSB], [https://www.ebi.ac.uk/pdbsum/2j8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8q ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8q ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Busam R]] |
| - | [[Category: Busam | + | [[Category: Collins R]] |
| - | [[Category: Collins | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Ericsson UB]] |
| - | [[Category: Ericsson | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Flores A]] |
| - | [[Category: Flores | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hallberg BM]] |
| - | [[Category: Hallberg | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Hogbom M]] |
| - | [[Category: Hogbom | + | [[Category: Holmberg SL]] |
| - | [[Category: Holmberg | + | [[Category: Johansson I]] |
| - | [[Category: Johansson | + | [[Category: Karlberg T]] |
| - | [[Category: Karlberg | + | [[Category: Kosinska U]] |
| - | [[Category: Kosinska | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotenyova | + | [[Category: Magnusdottir A]] |
| - | [[Category: Magnusdottir | + | [[Category: Moche M]] |
| - | [[Category: Moche | + | [[Category: Nilsson ME]] |
| - | [[Category: Nilsson | + | [[Category: Nilsson-Ehle P]] |
| - | [[Category: Nilsson-Ehle | + | [[Category: Nordlund P]] |
| - | [[Category: Nordlund | + | [[Category: Nyman T]] |
| - | [[Category: Nyman | + | [[Category: Ogg D]] |
| - | [[Category: Ogg | + | [[Category: Persson C]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | [[Category: Sagemark | + | [[Category: Stenmark P]] |
| - | [[Category: Stenmark | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Uppenberg J]] |
| - | [[Category: Uppenberg | + | [[Category: Upsten M]] |
| - | [[Category: Upsten | + | [[Category: Van Den Berg S]] |
| - | [[Category: | + | [[Category: Wallden K]] |
| - | [[Category: | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | |
| - | + | ||
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Current revision
Crystal structure of human cleavage and polyadenylation specificity factor 5 (CPSF5) in complex with a sulphate ion.
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berglund H | Busam R | Collins R | Edwards A | Ericsson UB | Flodin S | Flores A | Graslund S | Hallberg BM | Hammarstrom M | Hogbom M | Holmberg SL | Johansson I | Karlberg T | Kosinska U | Kotenyova T | Magnusdottir A | Moche M | Nilsson ME | Nilsson-Ehle P | Nordlund P | Nyman T | Ogg D | Persson C | Sagemark J | Stenmark P | Sundstrom M | Thorsell AG | Uppenberg J | Upsten M | Van Den Berg S | Wallden K | Weigelt J | Welin M
