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2jj3

From Proteopedia

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Current revision (09:38, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2jj3' size='340' side='right'caption='[[2jj3]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='2jj3' size='340' side='right'caption='[[2jj3]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jj3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jj3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJ3:(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL'>JJ3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x7b|1x7b]], [[1x7j|1x7j]], [[1yy4|1yy4]], [[2fsz|2fsz]], [[1l2j|1l2j]], [[1nde|1nde]], [[1qkm|1qkm]], [[1u3q|1u3q]], [[1u3r|1u3r]], [[1u3s|1u3s]], [[1u9e|1u9e]], [[1x76|1x76]], [[1x78|1x78]], [[1yye|1yye]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJ3:(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL'>JJ3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jj3 OCA], [https://pdbe.org/2jj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jj3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jj3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jj3 OCA], [https://pdbe.org/2jj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jj3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jj3 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dinn, S R]]
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[[Category: Dinn SR]]
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[[Category: Dodge, J A]]
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[[Category: Dodge JA]]
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[[Category: Durbin, J D]]
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[[Category: Durbin JD]]
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[[Category: Durst, G L]]
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[[Category: Durst GL]]
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[[Category: Krishnan, V]]
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[[Category: Krishnan V]]
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[[Category: Liu, S]]
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[[Category: Liu S]]
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[[Category: Norman, B H]]
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[[Category: Norman BH]]
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[[Category: Pfeifer, L A]]
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[[Category: Pfeifer LA]]
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[[Category: Reilly, J E]]
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[[Category: Reilly JE]]
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[[Category: Richardson, T I]]
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[[Category: Richardson TI]]
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[[Category: Ryter, K T]]
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[[Category: Ryter KT]]
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[[Category: Wang, Y]]
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[[Category: Wang Y]]
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[[Category: Alternative splicing]]
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[[Category: Dna-binding]]
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[[Category: Ligand binding domain]]
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[[Category: Lipid-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Receptor]]
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[[Category: Steroid-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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Current revision

Estrogen receptor beta ligand binding domain in complex with a Benzopyran agonist

PDB ID 2jj3

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OCA

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