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1g6u

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{{STRUCTURE_1g6u| PDB=1g6u | SCENE= }}
{{STRUCTURE_1g6u| PDB=1g6u | SCENE= }}
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'''CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER'''
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===CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER===
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==Overview==
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Three-dimensional (3D) domain-swapped proteins are intermolecularly folded analogs of monomeric proteins; both are stabilized by the identical interactions, but the individual domains interact intramolecularly in monomeric proteins, whereas they form intermolecular interactions in 3D domain-swapped structures. The structures and conditions of formation of several domain-swapped dimers and trimers are known, but the formation of higher order 3D domain-swapped oligomers has been less thoroughly studied. Here we contrast the structural consequences of domain swapping from two designed three-helix bundles: one with an up-down-up topology, and the other with an up-down-down topology. The up-down-up topology gives rise to a domain-swapped dimer whose structure has been determined to 1.5 A resolution by x-ray crystallography. In contrast, the domain-swapped protein with an up-down-down topology forms fibrils as shown by electron microscopy and dynamic light scattering. This demonstrates that design principles can predict the oligomeric state of 3D domain-swapped molecules, which should aid in the design of domain-swapped proteins and biomaterials.
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(as it appears on PubMed at http://www.pubmed.gov), where 11171963 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11171963}}
==About this Structure==
==About this Structure==
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[[Category: Ogihara, N L.]]
[[Category: Ogihara, N L.]]
[[Category: Designed three helix bundle]]
[[Category: Designed three helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:12:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:46:59 2008''

Revision as of 01:47, 1 July 2008

Image:1g6u.png

Template:STRUCTURE 1g6u

CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER

Template:ABSTRACT PUBMED 11171963

About this Structure

Full crystallographic information is available from OCA.

Reference

Design of three-dimensional domain-swapped dimers and fibrous oligomers., Ogihara NL, Ghirlanda G, Bryson JW, Gingery M, DeGrado WF, Eisenberg D, Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1404-9. PMID:11171963

Page seeded by OCA on Tue Jul 1 04:46:59 2008

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