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3c8o

From Proteopedia

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Current revision (14:56, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3c8o' size='340' side='right'caption='[[3c8o]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3c8o' size='340' side='right'caption='[[3c8o]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3c8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C8O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3c8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C8O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rraA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c8o OCA], [https://pdbe.org/3c8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c8o RCSB], [https://www.ebi.ac.uk/pdbsum/3c8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c8o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c8o OCA], [https://pdbe.org/3c8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c8o RCSB], [https://www.ebi.ac.uk/pdbsum/3c8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c8o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RRAAH_PSEAE RRAAH_PSEAE]] Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
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[https://www.uniprot.org/uniprot/RRAAH_PSEAE RRAAH_PSEAE] Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Huang, A]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Luo, M]]
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[[Category: Huang A]]
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[[Category: Niu, S]]
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[[Category: Luo M]]
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[[Category: Wang, D]]
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[[Category: Niu S]]
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[[Category: Yin, Y]]
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[[Category: Wang D]]
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[[Category: Hydrolase regulator]]
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[[Category: Yin Y]]
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[[Category: Pao1]]
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[[Category: Rnase e regulater]]
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[[Category: Rraa]]
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Current revision

The Crystal Structure of RraA from PAO1

PDB ID 3c8o

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