1g82

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1g82.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1g82.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1g82| PDB=1g82 | SCENE= }}
{{STRUCTURE_1g82| PDB=1g82 | SCENE= }}
-
'''STRUCTURE OF FIBROBLAST GROWTH FACTOR 9'''
+
===STRUCTURE OF FIBROBLAST GROWTH FACTOR 9===
-
==Overview==
+
<!--
-
Fibroblast growth factors (FGFs) constitute a family of at least 20 structurally related heparin-binding polypeptides active in regulating cell growth, survival, differentiation and migration. FGF9, originally discovered as a glia-activating factor, shares 30% sequence identity with other FGFs and has a unique spectrum of target-cell specificity. FGF9 crystallized in the tetragonal space group I4(1), with unit-cell parameters a = b = 151.9, c = 117.2 A. The structure of the glycosylated protein has been refined to an R value of 21.0% with R(free) = 24.8%) at 2.6 A resolution. The four molecules in the asymmetric unit are arranged in two non-crystallographic dimers, with the dimer interface composed partly of residues from N- and C-terminal extensions from the FGF core structure. Most of the receptor-binding residues identified in FGF1- and FGF2-receptor complexes are buried in the dimer interface, with the beta8-beta9 loop stabilized in a particular conformation by an intramolecular hydrogen-bonding network. The potential heparin-binding sites are in a pattern distinct from FGF1 and FGF2. The carbohydrate moiety attached at Asn79 has no structural influence.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11223514}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11223514 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11223514}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Yayon, A.]]
[[Category: Yayon, A.]]
[[Category: Fibroblast growth factor]]
[[Category: Fibroblast growth factor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:15:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:51:40 2008''

Revision as of 01:51, 1 July 2008

Image:1g82.png

Template:STRUCTURE 1g82

STRUCTURE OF FIBROBLAST GROWTH FACTOR 9

Template:ABSTRACT PUBMED 11223514

About this Structure

1G82 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces., Hecht HJ, Adar R, Hofmann B, Bogin O, Weich H, Yayon A, Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):378-84. PMID:11223514

Page seeded by OCA on Tue Jul 1 04:51:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g82"
Personal tools