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7szl
From Proteopedia
(Difference between revisions)
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==Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)== | ==Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)== | ||
| - | <StructureSection load='7szl' size='340' side='right'caption='[[7szl]]' scene=''> | + | <StructureSection load='7szl' size='340' side='right'caption='[[7szl]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7szl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Toll/interleukin-1 receptor (TIR) domains are key innate immune signaling modules. Here, we present the crystal structure of the TIR domain of human Interleukin-1 receptor 10 (IL-1R10), also called IL-1RAPL2. It is similar to that of IL-1R9 (IL-1RAPL1) but shows significant structural differences to those from Toll-like receptors (TLRs) and the adaptor proteins MAL and MyD88. Interactions of TIR domains in their respective crystals and the higher-order assemblies (MAL and MyD88) reveal the presence of a common 'BCD surface', suggesting its functional significance. We also show that the TIR domains of IL-1R10 and IL-1R9 lack NADase activity, consistent with their structures. Our study provides a foundation for unraveling the functions of IL-1R9 and IL-1R10. | ||
| + | |||
| + | Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1R10 provides structural insights into TIR domain signaling.,Nimma S, Gu W, Manik MK, Ve T, Nanson JD, Kobe B FEBS Lett. 2022 Jan 17. doi: 10.1002/1873-3468.14288. PMID:35038778<ref>PMID:35038778</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7szl" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Gu W]] | + | [[Category: Gu, W]] |
| - | [[Category: Kobe B]] | + | [[Category: Kobe, B]] |
| - | [[Category: Manik | + | [[Category: Manik, M K]] |
| - | [[Category: Nanson | + | [[Category: Nanson, J D]] |
| - | [[Category: Nimma S]] | + | [[Category: Nimma, S]] |
| - | [[Category: Ve T]] | + | [[Category: Ve, T]] |
| + | [[Category: Immune system]] | ||
| + | [[Category: Interleukin-1 receptor]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Tir domain]] | ||
Revision as of 03:09, 21 April 2022
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)
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