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7ny6
From Proteopedia
(Difference between revisions)
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<StructureSection load='7ny6' size='340' side='right'caption='[[7ny6]], [[Resolution|resolution]] 1.34Å' scene=''> | <StructureSection load='7ny6' size='340' side='right'caption='[[7ny6]], [[Resolution|resolution]] 1.34Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7ny6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NY6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ny6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capsaspora_owczarzaki_ATCC_30864 Capsaspora owczarzaki ATCC 30864]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NY6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ny6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ny6 OCA], [https://pdbe.org/7ny6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ny6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ny6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ny6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ny6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ny6 OCA], [https://pdbe.org/7ny6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ny6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ny6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ny6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/H2AY_CAPO3 H2AY_CAPO3] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[UniProtKB:O93327] Specifically binds poly-ADP-ribose and plays a key role in NAD(+) metabolism (PubMed:34887560). Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (PubMed:34887560). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (PubMed:34887560).<ref>PMID:34887560</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Capsaspora owczarzaki ATCC 30864]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Basquin | + | [[Category: Basquin J]] |
| - | [[Category: Buschbeck | + | [[Category: Buschbeck M]] |
| - | [[Category: Guberovic | + | [[Category: Guberovic I]] |
| - | [[Category: Knobloch | + | [[Category: Knobloch G]] |
| - | [[Category: Ladurner | + | [[Category: Ladurner AG]] |
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Current revision
Crystal structure of the Capsaspora owczarzaki macroH2A macrodomain
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