1wmi

<table><tr><td colspan='2'>[[1wmi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMI FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmi OCA], [https://pdbe.org/1wmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmi RCSB], [https://www.ebi.ac.uk/pdbsum/1wmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmi ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The Escherichia coli chromosome encodes toxin-antitoxin pairs. The toxin RelE cleaves mRNA positioned at the A-site in ribosomes, whereas the antitoxin RelB relieves the effect of RelE. The hyperthermophilic archaeon Pyrococcus horikoshii OT3 has the archaeal homologs aRelE and aRelB. Here we report the crystal structure of aRelE in complex with aRelB determined at a resolution of 2.3 A. aRelE folds into an alpha/beta structure, whereas aRelB lacks a distinct hydrophobic core and extensively wraps around the molecular surface of aRelE. Neither component shows structural homology to known ribonucleases or their inhibitors. Site-directed mutagenesis suggests that Arg85, in the C-terminal region, is strongly involved in the functional activity of aRelE, whereas Arg40, Leu48, Arg58 and Arg65 play a modest role in the toxin's activity.

Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects.,Takagi H, Kakuta Y, Okada T, Yao M, Tanaka I, Kimura M Nat Struct Mol Biol. 2005 Apr;12(4):327-31. Epub 2005 Mar 13. PMID:15768033<ref>PMID:15768033</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Pyrococcus horikoshii]]

[[Category: Kakuta, Y]]

[[Category: Kamachi, R]]

[[Category: Kimura, M]]

[[Category: Takagi, H]]

[[Category: Tanaka, I]]

[[Category: Yao, M]]

[[Category: Toxin-antitoxin complex]]