1dk8
From Proteopedia
(New page: 200px<br /> <applet load="1dk8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dk8, resolution 1.57Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1dk8. | + | [[Image:1dk8.jpg|left|200px]]<br /><applet load="1dk8" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1dk8, resolution 1.57Å" /> | caption="1dk8, resolution 1.57Å" /> | ||
'''CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN'''<br /> | '''CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DK8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, DTT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1DK8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=DTT:'>DTT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DK8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: pi-helix]] | [[Category: pi-helix]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:40:09 2008'' |
Revision as of 13:40, 15 February 2008
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CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN
Contents |
Overview
Axin and the adenomatous polyposis coli (APC) tumor suppressor protein are, components of the Wnt/Wingless growth factor signaling pathway. In the, absence of Wnt signal, Axin and APC regulate cytoplasmic levels of the, proto-oncogene beta-catenin through the formation of a large complex, containing these three proteins, glycogen synthase kinase 3beta (GSK3beta), and several other proteins. Both Axin and APC are known to be critical for, beta-catenin regulation, and truncations in APC that eliminate the, Axin-binding site result in human cancers. A protease-resistant domain of, Axin that contains the APC-binding site is a member of the regulators of, G-protein signaling (RGS) superfamily. The crystal structures of this, domain alone and in complex with an Axin-binding sequence from APC reveal, that the Axin-APC interaction occurs at a conserved groove on a face of, the protein that is distinct from the G-protein interface of classical RGS, proteins. The molecular interactions observed in the Axin-APC complex, provide a rationale for the evolutionary conservation seen in both, proteins.
Disease
Known diseases associated with this structure: Caudal duplication anomaly OMIM:[603816], Hepatocellular carcinoma, somatic OMIM:[603816]
About this Structure
1DK8 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis of the Axin-adenomatous polyposis coli interaction., Spink KE, Polakis P, Weis WI, EMBO J. 2000 May 15;19(10):2270-9. PMID:10811618
Page seeded by OCA on Fri Feb 15 15:40:09 2008
Categories: Homo sapiens | Single protein | Polakis, P. | Spink, K.E. | Weis, W.I. | DTT | GOL | SO4 | Alpha-helix | Pi-helix
