1gab

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{{STRUCTURE_1gab| PDB=1gab | SCENE= }}
{{STRUCTURE_1gab| PDB=1gab | SCENE= }}
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'''STRUCTURE OF AN ALBUMIN-BINDING DOMAIN, NMR, 20 STRUCTURES'''
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===STRUCTURE OF AN ALBUMIN-BINDING DOMAIN, NMR, 20 STRUCTURES===
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==Overview==
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The albumin-binding GA module is found in a family of surface proteins of different bacterial species. It comprises 45 amino acid residues and represents the first known example of contemporary module shuffling. Using 1H NMR spectroscopy we have determined the solution structure of the GA module from protein PAB, a protein of the anaerobic human commensal and pathogen Peptostreptococcus magnus. This structure, the first three-dimensional structure of an albumin-binding protein domain described, was shown to be composed of a left-handed three-helix-bundle. Sequence differences between GA modules with different affinities for albumin indicated that a conserved region in the C-terminal part of the second helix and the flexible sequence between helices 2 and 3 could contribute to the albumin-binding activity. The effect on backbone amide proton exchange rates upon binding to albumin support this assumption. The GA module has a fold that is strikingly similar to the immunoglobulin-binding domains of staphylococcal protein A but it shows no resemblance to the fold shared by the immunoglobulin-binding domains of streptococcal protein G and peptostreptococcal protein L. When the gene sequences, binding properties and thermal stability of these four domains are analysed in relation to their global folds an evolutionary pattern emerges. Thus, in the evolution of novel binding properties mutations are allowed only as long as the energetically favourable global fold is maintained.
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(as it appears on PubMed at http://www.pubmed.gov), where 9086265 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9086265}}
==About this Structure==
==About this Structure==
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1GAB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Finegoldia_magna Finegoldia magna]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GAB OCA].
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1GAB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Finegoldia_magna Finegoldia magna]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GAB OCA].
==Reference==
==Reference==
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[[Category: Evolution]]
[[Category: Evolution]]
[[Category: Module shuffling]]
[[Category: Module shuffling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:59:12 2008''

Revision as of 01:59, 1 July 2008

Image:1gab.png

Template:STRUCTURE 1gab

STRUCTURE OF AN ALBUMIN-BINDING DOMAIN, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9086265

About this Structure

1GAB is a Single protein structure of sequence from Finegoldia magna. Full experimental information is available from OCA.

Reference

Solution structure of the albumin-binding GA module: a versatile bacterial protein domain., Johansson MU, de Chateau M, Wikstrom M, Forsen S, Drakenberg T, Bjorck L, J Mol Biol. 1997 Mar 14;266(5):859-65. PMID:9086265

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