1gam

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{{STRUCTURE_1gam| PDB=1gam | SCENE= }}
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'''GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN'''
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===GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN===
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==Overview==
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We use protein engineering and crystallography to simulate aspects of the early evolution of beta gamma-crystallins by observing how a single domain oligomerizes in response to changes in a sequence extension. The crystal structure of the C-terminal domain of gamma beta-crystallin with its four-residue C-terminal extension shows that the domain does not form a symmetric homodimer analogous to the two-domain pairing in beta gamma-crystallins. Instead the C-terminal extension now forms heterologous interactions with other domains leading to the solvent exposure of the natural hydrophobic interface with a consequent loss in protein solubility. However, this domain truncated by just the C-terminal tyrosine forms a symmetric homodimer of domains in the crystal lattice.
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(as it appears on PubMed at http://www.pubmed.gov), where 8605629 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8605629}}
==About this Structure==
==About this Structure==
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[[Category: Gamma crystallin b]]
[[Category: Gamma crystallin b]]
[[Category: Multigene family]]
[[Category: Multigene family]]
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Revision as of 02:00, 1 July 2008

Image:1gam.png

Template:STRUCTURE 1gam

GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 8605629

About this Structure

1GAM is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins., Norledge BV, Mayr EM, Glockshuber R, Bateman OA, Slingsby C, Jaenicke R, Driessen HP, Nat Struct Biol. 1996 Mar;3(3):267-74. PMID:8605629

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