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7tsq

From Proteopedia

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m (Protected "7tsq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7tsq is ON HOLD until Paper Publication
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==Structure of Enterobacter cloacae Cap2 bound to CdnD02 C-terminus, AMP state==
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<StructureSection load='7tsq' size='340' side='right'caption='[[7tsq]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7tsq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsq OCA], [https://pdbe.org/7tsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsq RCSB], [https://www.ebi.ac.uk/pdbsum/7tsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDND2_ENTCL CDND2_ENTCL] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-C(AAG) CBASS system (PubMed:32839535).<ref>PMID:32544385</ref> <ref>PMID:32839535</ref> Cyclic trinucleotide synthase that catalyzes the synthesis of 3',3',3'-cyclic AMP-AMP-GMP as the major product, a second messenger for cell signal transduction.<ref>PMID:30787435</ref> Protects E.coli against phage T2 infection. When the cdnD-cap2-cap3-cap4 operon is introduced in E.coli there is a more than 10(3) decrease in the efficiency of T2 plaque formation. The operon does not protect against phage T5 and only about 10-fold against T7.<ref>PMID:32544385</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Enterobacter cloacae]]
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[[Category: Large Structures]]
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[[Category: Corbett KD]]
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[[Category: Gu Y]]
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[[Category: Lau RK]]
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[[Category: Ledvina HE]]
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[[Category: Quan Y]]
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[[Category: Whiteley AT]]
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[[Category: Ye Q]]
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[[Category: Zhou H]]

Revision as of 07:33, 11 January 2023

Structure of Enterobacter cloacae Cap2 bound to CdnD02 C-terminus, AMP state

PDB ID 7tsq

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