2lld
From Proteopedia
(Difference between revisions)
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==The Insect Defensin Lucifensin from Lucilia sericata== | ==The Insect Defensin Lucifensin from Lucilia sericata== | ||
| - | <StructureSection load='2lld' size='340' side='right'caption='[[2lld | + | <StructureSection load='2lld' size='340' side='right'caption='[[2lld]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2lld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2lld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_sericata Lucilia sericata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LLD FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lld OCA], [https://pdbe.org/2lld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lld RCSB], [https://www.ebi.ac.uk/pdbsum/2lld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lld ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lld OCA], [https://pdbe.org/2lld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lld RCSB], [https://www.ebi.ac.uk/pdbsum/2lld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lld ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DEFLU_LUCSE DEFLU_LUCSE] Shows strong antibacterial activity against numerous Gram-positive bacteria. It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). Shows antibacterial activity against the Gram-positive bacteria M.luteus, E.fecalis (MIC=32 mg/L), S.aureus (MIC=16 mg/L), S.carnosus (MIC=2 mg/L), S.pneumoniae (MIC=2 mg/L) and S.pyogenes (MIC=2 mg/L) and against a number of methicillin-resistant S.aureus and glycopeptide-intermediate S.aureus isolates (PubMed:20542901, PubMed:19921400, PubMed:21560219). Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C.utilis (PubMed:20542901). Shows slight antifungal activity against C.albicans (PubMed:21560219).<ref>PMID:19921400</ref> <ref>PMID:20542901</ref> <ref>PMID:21560219</ref> <ref>PMID:20508130</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Green bottle fly]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Andersen | + | [[Category: Lucilia sericata]] |
| - | [[Category: Fojan | + | [[Category: Andersen AS]] |
| - | [[Category: Kristensen | + | [[Category: Fojan P]] |
| - | [[Category: Krogfelt | + | [[Category: Kristensen H]] |
| - | [[Category: Nygaard | + | [[Category: Krogfelt KA]] |
| - | [[Category: Wimmer | + | [[Category: Nygaard MKE]] |
| - | + | [[Category: Wimmer R]] | |
| - | + | ||
| - | + | ||
Revision as of 09:03, 14 June 2023
The Insect Defensin Lucifensin from Lucilia sericata
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