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3dyq

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Current revision (12:55, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3dyq' size='340' side='right'caption='[[3dyq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3dyq' size='340' side='right'caption='[[3dyq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DYQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DYQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dy8|3dy8]], [[3dyl|3dyl]], [[3dyn|3dyn]], [[3dys|3dys]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE9A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyq OCA], [https://pdbe.org/3dyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dyq RCSB], [https://www.ebi.ac.uk/pdbsum/3dyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyq OCA], [https://pdbe.org/3dyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dyq RCSB], [https://www.ebi.ac.uk/pdbsum/3dyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN]] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
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[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Danley, D]]
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[[Category: Danley D]]
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[[Category: Dillman, K]]
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[[Category: Dillman K]]
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[[Category: Liu, S]]
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[[Category: Liu S]]
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[[Category: Mansour, M N]]
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[[Category: Mansour MN]]
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[[Category: Menniti, F]]
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[[Category: Menniti F]]
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[[Category: Perez, J]]
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[[Category: Perez J]]
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[[Category: Cgmp]]
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[[Category: Enzyme mechanism]]
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[[Category: Hydrolase]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Phosphodiesterase]]
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[[Category: Phosphoprotein]]
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Current revision

human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP

PDB ID 3dyq

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OCA

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