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3e17

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Current revision (15:16, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3e17' size='340' side='right'caption='[[3e17]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='3e17' size='340' side='right'caption='[[3e17]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3e17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E17 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3e17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E17 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TJP2, X104, ZO2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e17 OCA], [https://pdbe.org/3e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e17 RCSB], [https://www.ebi.ac.uk/pdbsum/3e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e17 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e17 OCA], [https://pdbe.org/3e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e17 RCSB], [https://www.ebi.ac.uk/pdbsum/3e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e17 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[https://omim.org/entry/607748 607748]]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref>
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[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[https://omim.org/entry/607748 607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Plays a role in tight junctions and adherens junctions.
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[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Plays a role in tight junctions and adherens junctions.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, H]]
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[[Category: Chen H]]
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[[Category: Niu, L W]]
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[[Category: Niu LW]]
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[[Category: Teng, M K]]
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[[Category: Teng MK]]
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[[Category: Tong, S L]]
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[[Category: Tong SL]]
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[[Category: Alternative promoter usage]]
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[[Category: Alternative splicing]]
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[[Category: Cell adhesion]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Disease mutation]]
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[[Category: Domain swapping]]
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[[Category: Membrane]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Sh3 domain]]
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[[Category: Tight junction]]
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Current revision

Crystal structure of the second PDZ domain from human Zona Occludens-2

PDB ID 3e17

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