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Introduction

Function and Biological Role

Gq

Gi

Significance of Human Itch GPCR

nobel prize, methods of visualization, and the history of known diseases and their associated mutations

Related Enzymes

X2 vs. X4

Structure

conserved domains and subunits: 7TM helices, etc. interactions with the Gq and Gi proteins

Active Site

important residues the two binding pockets (electrostatics) difference between the binding pockets of X2 and X4; talk about why these differences affect the type of ligands that may bind

Substrates/Ligands

Talk about there a ton of different ligands can bind Highlight the few that we want to talk about: Peptide vs. manufactured/artificial vs. non-peptide Agonists, inverse agonists, and antagonists and their effects on the mechanism

Mechanism

mechanism of binding and the associated chemical interactions signaling cascades associated with the Human Itch GPCRs regulatory processes within the signaling cascade that directly affect the g-proteins

Relevance

Implications for Disease

significant mutations that have been found drug design for GPCR targeting

Clinical Relevance

drug hypersensitivity article

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