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1gcj

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[[Image:1gcj.gif|left|200px]]
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{{STRUCTURE_1gcj| PDB=1gcj | SCENE= }}
{{STRUCTURE_1gcj| PDB=1gcj | SCENE= }}
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'''N-TERMINAL FRAGMENT OF IMPORTIN-BETA'''
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===N-TERMINAL FRAGMENT OF IMPORTIN-BETA===
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==Overview==
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Importin-beta is a nuclear transport factor which mediates the nuclear import of various nuclear proteins. The N-terminal 1-449 residue fragment of mouse importin-beta (impbeta449) possesses the ability to bidirectionally translocate through the nuclear pore complex (NPC), and to bind RanGTP. The structure of the uncomplexed form of impbeta449 has been solved at a 2.6 A resolution by X-ray crystallography. It consists of ten copies of the tandemly arrayed HEAT repeat and exhibits conformational flexibility which is involved in protein-protein interaction for nuclear transport. The overall conformation of the HEAT repeats shows that a twisted motion produces a significantly varied superhelical architecture from the previously reported structure of RanGTP-bound importin-beta. These conformational changes appear to be the sum of small conformational changes throughout the polypeptide. Such a flexibility, which resides in the stacked HEAT repeats, is essential for interaction with RanGTP or with NPCs. Furthermore, it was found that impbeta449 has a structural similarity with another nuclear migrating protein, namely beta-catenin, which is composed of another type of helix-repeated structure of ARM repeat. Interestingly, the essential regions for NPC translocation for both importin-beta and beta-catenin are spatially well overlapped with one another. This strongly indicates the importance of helix stacking of the HEAT or ARM repeats for NPC-passage.
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(as it appears on PubMed at http://www.pubmed.gov), where 10964573 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10964573}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear import factor]]
[[Category: Nuclear import factor]]
[[Category: Nuclear pore-targeting complex component]]
[[Category: Nuclear pore-targeting complex component]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:24:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:04:56 2008''

Revision as of 02:04, 1 July 2008

Image:1gcj.png

Template:STRUCTURE 1gcj

N-TERMINAL FRAGMENT OF IMPORTIN-BETA

Template:ABSTRACT PUBMED 10964573

About this Structure

1GCJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport., Lee SJ, Imamoto N, Sakai H, Nakagawa A, Kose S, Koike M, Yamamoto M, Kumasaka T, Yoneda Y, Tsukihara T, J Mol Biol. 2000 Sep 8;302(1):251-64. PMID:10964573

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