This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1gcp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1gcp.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1gcp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1gcp| PDB=1gcp | SCENE= }}
{{STRUCTURE_1gcp| PDB=1gcp | SCENE= }}
-
'''CRYSTAL STRUCTURE OF VAV SH3 DOMAIN'''
+
===CRYSTAL STRUCTURE OF VAV SH3 DOMAIN===
-
==Overview==
+
<!--
-
Vav is a guanine nucleotide exchange factor for the Rho/Rac family that is expressed exclusively in hematopoietic cells. Growth factor receptor-bound protein 2 (Grb2) has been proposed to play important roles in the membrane localization and activation of Vav through dimerization of its C-terminal Src-homology 3 (SH3) domain (GrbS) and the N-terminal SH3 domain of Vav (VavS). The crystal structure of VavS complexed with GrbS has been solved. VavS is distinct from other SH3 domain proteins in that its binding site for proline-rich peptides is blocked by its own RT loop. One of the ends of the VavS beta-barrel forms a concave hydrophobic surface. The GrbS components make a contiguous complementary interface with the VavS surface. The binding site of GrbS for VavS partially overlaps with the canonical binding site for proline-rich peptides, but is definitely different. Mutations at the interface caused a decrease in the binding affinity of VavS for GrbS by 4- to 40-fold. The structure reveals how GrbS discriminates VavS specifically from other signaling molecules without binding to the proline-rich motif.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11406576}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11406576 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11406576}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Ogura, K.]]
[[Category: Ogura, K.]]
[[Category: Sh3 domain,vav]]
[[Category: Sh3 domain,vav]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:25:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:06:26 2008''

Revision as of 02:06, 1 July 2008

Image:1gcp.png

Template:STRUCTURE 1gcp

CRYSTAL STRUCTURE OF VAV SH3 DOMAIN

Template:ABSTRACT PUBMED 11406576

About this Structure

1GCP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Novel recognition mode between Vav and Grb2 SH3 domains., Nishida M, Nagata K, Hachimori Y, Horiuchi M, Ogura K, Mandiyan V, Schlessinger J, Inagaki F, EMBO J. 2001 Jun 15;20(12):2995-3007. PMID:11406576

Page seeded by OCA on Tue Jul 1 05:06:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gcp"
Personal tools